Flygut: an atlas of the Drosophila adult midgut

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Gene name Krn
Flybase description The gene Keren is referred to in FlyBase by the symbol Dmel\Krn (CG32179, FBgn0052179).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.8074 -1.6807 -3.005177 -1.8464 -5.838758 -3.1853 -2.65492 -3.676236
    Affimetrix absolute value 6.143 6.871 6.639 7.53 6.273 6.903 7.168 6.419
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: growth factor activity; epidermal growth factor receptor binding.
There is experimental evidence that it is involved in the biological process: border follicle cell migration; positive regulation of cell proliferation; MAPKKK cascade; compound eye development; regulation of epidermal growth factor receptor signaling pathway; positive regulation of epidermal growth factor receptor activity; ommatidial rotation.
22 alleles are reported.
The phenotypes of these alleles are annotated with: adult midgut precursor cell; eye; cephalopharyngeal skeleton; midgut; border follicle cell; wing; ommatidium; denticle belt.
It has one annotated transcript and one annotated polypeptide.
Protein features are: EGF; EGF-like region, conserved site; Epidermal growth factor-like; Epidermal growth factor-like, type 3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period.
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