Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name al
Flybase description The gene aristaless is referred to in FlyBase by the symbol Dmel\al (CG3935, FBgn0000061).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -25.3195 -13.8901 -16.335385 -19.7764 -26.504351 -26.1523 -23.96837 -18.454788
    Affimetrix absolute value 3.76 3.837 4.206 4.09 4.049 3.855 3.968 4.092
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: bristle development; antennal morphogenesis; positive regulation of Notch signaling pathway; leg disc development; imaginal disc-derived leg morphogenesis; elongation of arista core; negative regulation of transcription, DNA-dependent.
28 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: adult segment; organ system subdivision; adult mesothoracic segment; appendage segment; external compound sense organ; antennal segment; compound cell cluster organ; unguis; integumentary plate; mesothoracic preepisternum.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Helix-turn-helix motif, lambda-like repressor; Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Paired-like homeodomain protein, OAR.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 12-18 embryonic stages.