Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Appl
Flybase description The gene β amyloid protein precursor-like is referred to in FlyBase by the symbol Dmel\Appl (CG7727, FBgn0000108).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -47.7554 -24.1763 -36.018771 -43.6142 -61.706175 -55.4959 -61.88699 -44.465409
    Affimetrix absolute value 2.832 3.031 3.018 2.963 2.821 2.773 2.601 2.786
    Affymetric present call in "x" number of chips 0 1 0 0 0 0 0 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: neuron projection morphogenesis; long-term memory; response to axon injury; peripheral nervous system development; synapse organization.
28 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; adult segment; nervous system; adult mesothoracic segment; peripheral nervous system; sensillum; organ system; eo support cell; external compound sense organ; wing pouch.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: Amyloidogenic glycoprotein, copper-binding; Amyloidogenic glycoprotein, extracellular; Amyloidogenic glycoprotein, extracellular domain conserved site; Amyloidogenic glycoprotein, heparin-binding; Amyloidogenic glycoprotein, intracellular domain, conserved site; Beta-amyloid precursor protein C-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages.