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|Flybase description||The gene big brain is referred to in FlyBase by the symbol Dmel\bib (CG4722, FBgn0000180).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cation channel activity.
There is experimental evidence that it is involved in the biological process: endosomal lumen acidification; lateral inhibition; endosome organization; cell-cell adhesion; mesoderm development.
29 alleles are reported.
The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; non-connected developing system; portion of tissue; somatic cell; multicellular structure; sense organ; sensillum; organ system subdivision; presumptive embryonic/larval nervous system; nervous system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Aquaporin; Aquaporin-like; Major intrinsic protein; Major intrinsic protein, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.