Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name cact
Flybase description The gene cactus is referred to in FlyBase by the symbol Dmel\cact (CG5848, FBgn0000250).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.6539 -5.4557 -25.053523 -18.2289 -39.889617 -17.8741 -7.63649 -20.917144
    Affimetrix absolute value 7.03 5.181 3.545 4.217 3.461 4.403 5.661 3.977
    Affymetric present call in "x" number of chips 3 3 0 3 0 3 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: antifungal humoral response; nervous system development; dorsal/ventral axis specification; oogenesis; antimicrobial humoral response; positive regulation of antifungal peptide biosynthetic process; response to DNA damage stimulus; dorsal appendage formation; phagocytosis, engulfment.
131 alleles are reported.
The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; embryonic/larval hemocoel; portion of tissue; hemocyte; non-connected developing system; multicellular structure; cuticle; egg; podocyte; spiracle.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-06 and 18-24 hour embryonic stages.