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|Flybase description||The gene Clathrin heavy chain is referred to in FlyBase by the symbol Dmel\Chc (CG9012, FBgn0000319).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding; structural molecule activity.
There is experimental evidence that it is involved in the biological process: sperm individualization; positive regulation of Notch signaling pathway; dsRNA transport; endocytosis; positive regulation of endocytosis; liquid clearance, open tracheal system; regulation of tube length, open tracheal system; regulation of growth; extracellular matrix organization; compound eye retinal cell programmed cell death.
25 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: cytoplasmic part; organ system; organelle; external compound sense organ; nervous system; organ system subdivision; intracellular membrane-bounded organelle; synapse; peripheral nervous system; non-connected developing system; imaginal precursor; spermatozoon; garland cell.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: Armadillo-type fold; Clathrin, heavy chain; Clathrin, heavy chain, linker, core motif; Clathrin, heavy chain, linker/propeller domain; Clathrin, heavy chain, propeller repeat; Clathrin, heavy chain, propeller, N-terminal; Clathrin, heavy chain/VPS, 7-fold repeat; Tetratricopeptide-like helical.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.