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|Flybase description||The gene costa is referred to in FlyBase by the symbol Dmel\cos (CG1708, FBgn0000352).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: smoothened binding; microtubule binding; protein binding; protein kinase binding; transcription factor binding.
There is experimental evidence that it is involved in the biological process: smoothened signaling pathway; regulation of protein stability; negative regulation of sequence-specific DNA binding transcription factor activity; imaginal disc-derived wing morphogenesis; cytoplasmic sequestering of transcription factor; negative regulation of transcription factor import into nucleus; positive regulation of hh target transcription factor activity.
89 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; adult segment; organ system; adult mesothoracic segment; thoracic segment; imaginal precursor; dorsal thoracic disc; vagina; vulva; larval thorax; epiproct; non-connected developing system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Kinesin, motor domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.