Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name crc
Flybase description The gene cryptocephal is referred to in FlyBase by the symbol Dmel\crc (CG8669, FBgn0000370).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 13.5362 13.9906 6.400379 5.9096 3.109111 3.8738 9.33544 5.956964
    Affimetrix absolute value 12.163 11.405 10.854 10.931 10.391 10.498 11.739 10.792
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; protein heterodimerization activity.
There is experimental evidence that it is involved in the biological process: metamorphosis; molting cycle, chitin-based cuticle; regulation of transcription, DNA-dependent; pupation; pupariation.
18 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system subdivision; adult segment; thoracic segment; organ system; adult mesothoracic segment; larval thorax; dorsal thoracic disc; adult cuticle; spiracle; cephalopharyngeal skeleton.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Basic-leucine zipper (bZIP) transcription factor; bZIP transcription factor, bZIP-1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.