Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Dab
Flybase description The gene Disabled is referred to in FlyBase by the symbol Dmel\Dab (CG9695, FBgn0000414).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.9668 -6.5667 -29.659658 -23.3388 -36.832756 -21.5182 -3.17093 -20.936784
    Affimetrix absolute value 6.117 4.922 3.294 3.883 3.557 4.134 6.936 3.885
    Affymetric present call in "x" number of chips 3 3 0 0 0 0 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: SH2 domain binding; protein binding; SH3 domain binding.
There is experimental evidence that it is involved in the biological process: synaptic vesicle endocytosis; motor axon guidance; dorsal closure; sevenless signaling pathway; cellularization; clathrin-mediated endocytosis; compound eye photoreceptor development; neurogenesis.
18 alleles are reported.
The phenotypes of these alleles are annotated with: synapse; synaptic vesicle; bouton.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Phosphotyrosine interaction domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages.