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|Flybase description||The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
There is experimental evidence that it is involved in the biological process: synaptic transmission; conditioned taste aversion; short-term memory; learning; axon extension; lateral inhibition.
72 alleles are reported.
The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system subdivision; organ system; embryonic/larval neuron; nervous system; synapse; peripheral nervous system; female germline cyst; egg; synaptic neuropil subdomain; postsynaptic membrane.
It has 12 annotated transcripts and 12 annotated polypeptides.
Protein features are: 3'5'-cyclic nucleotide phosphodiesterase; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 3'5'-cyclic nucleotide phosphodiesterase, conserved site; Metal-dependent phosphohydrolase, HD domain; Twin-arginine translocation pathway, signal sequence.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.