Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Dr
Flybase description The gene Drop is referred to in FlyBase by the symbol Dmel\Dr (CG1897, FBgn0000492).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.523 -37.3697 -57.452708 -73.8384 -83.245763 -72.7532 -66.73626 -43.707568
    Affimetrix absolute value 7.812 2.419 2.335 2.212 2.381 2.382 2.512 2.849
    Affymetric present call in "x" number of chips 3 0 1 0 0 0 0 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; DNA binding.
There is experimental evidence that it is involved in the biological process: glial cell development; dorsal/ventral pattern formation, imaginal disc; wing and notum subfield formation; imaginal disc-derived male genitalia development; brain development; imaginal disc-derived wing morphogenesis; regulation of cell fate specification; wing disc pattern formation.
57 alleles are reported.
The phenotypes of these alleles are annotated with 168 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; A1-7 oblique muscle; A1-7 transverse muscle; larval abdominal segment 5; hypodermal muscle of metathorax; organ system subdivision; thoracic segment; hypodermal muscle of mesothorax; A1-7 ventral acute muscle 2.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Homeobox; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 06-12 hour embryonic stages.