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|Flybase description||The gene engrailed is referred to in FlyBase by the symbol Dmel\en (CG9015, FBgn0000577).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: anterior commissure morphogenesis; neuroblast fate determination; axon guidance; spiracle morphogenesis, open tracheal system; gonad development; ventral midline development; genital disc development; genital disc anterior/posterior pattern formation.
184 alleles are reported.
The phenotypes of these alleles are annotated with 91 unique terms, many of which group under: organ system subdivision; adult segment; abdominal ventral denticle belt; adult mesothoracic segment; multi-cell-component structure; organ system; presumptive embryonic/larval nervous system; embryonic/larval neuron; antennal segment; nervous system.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-turn-helix motif, lambda-like repressor; Homeobox; Homeobox engrailed; Homeobox engrailed, C-terminal; Homeobox engrailed-type, conserved site; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.