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|Flybase description||The gene α actinin is referred to in FlyBase by the symbol Dmel\Actn (CG4376, FBgn0000667).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: calcium ion binding; actin filament binding; actin binding.
There is experimental evidence that it is involved in the biological process: flight behavior; sarcomere organization; actin cytoskeleton reorganization.
43 alleles are reported.
The phenotypes of these alleles are annotated with: Z disc; eye; trichogen cell; myofibril; ovariole; somatic muscle; sarcomere; third instar larva; indirect flight muscle; muscle cell.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Actinin-type, actin-binding, conserved site; Calcium-binding EF-hand; Calponin homology domain; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand, Ca insensitive; EF-hand-like domain; Spectrin repeat; Spectrin/alpha-actinin.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes.