Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Actn
Flybase description The gene α actinin is referred to in FlyBase by the symbol Dmel\Actn (CG4376, FBgn0000667).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 2.4278 -1.36 -3.870955 -2.895 -4.58723 -2.692 1.61123 -2.156739
    Affimetrix absolute value 9.675 7.197 6.241 6.858 6.563 7.136 9.222 7.184
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: calcium ion binding; actin filament binding; actin binding.
There is experimental evidence that it is involved in the biological process: flight behavior; sarcomere organization; actin cytoskeleton reorganization.
43 alleles are reported.
The phenotypes of these alleles are annotated with: Z disc; eye; trichogen cell; myofibril; ovariole; somatic muscle; sarcomere; third instar larva; indirect flight muscle; muscle cell.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Actinin-type, actin-binding, conserved site; Calcium-binding EF-hand; Calponin homology domain; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand, Ca insensitive; EF-hand-like domain; Spectrin repeat; Spectrin/alpha-actinin.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes.