Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Fps85D
Flybase description The gene Fps oncogene analog is referred to in FlyBase by the symbol Dmel\Fps85D (CG8874, FBgn0000723).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.2612 1.3074 -1.496848 -3.3327 -2.492522 -1.1391 -1.61723 -1.863887
    Affimetrix absolute value 8.732 7.983 7.61 6.672 7.45 8.383 7.868 7.38
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity.
There is experimental evidence that it is involved in the biological process: dorsal closure, elongation of leading edge cells; dorsal closure; actin filament bundle assembly; axon guidance; photoreceptor cell morphogenesis; dorsal closure, amnioserosa morphology change.
19 alleles are reported.
The phenotypes of these alleles are annotated with: dorsal closure embryo; amnioserosa; ventral midline.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Fps/Fes/Fer/CIP4 homology; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages.