Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name grk
Flybase description The gene gurken is referred to in FlyBase by the symbol Dmel\grk (CG17610, FBgn0001137).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.5983 -4.7991 -12.090048 -10.499 -16.418855 -11.3801 -3.64837 -11.794656
    Affimetrix absolute value 7.766 5.394 4.59 4.998 4.735 5.054 6.692 4.709
    Affymetric present call in "x" number of chips 3 3 0 3 3 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: gurken receptor binding; epidermal growth factor receptor binding.
There is experimental evidence that it is involved in the biological process: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded; establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; oocyte microtubule cytoskeleton organization; border follicle cell migration; chorion-containing eggshell pattern formation.
80 alleles are reported.
The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: egg; organ system; female germline cyst; adult segment; chorion; organ system subdivision; adult mesothoracic segment; portion of tissue; epithelial furrow; cell part.
It has one annotated transcript and one annotated polypeptide.
Protein features are: EGF-like region, conserved site; Epidermal growth factor-like; Epidermal growth factor-like, type 3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed during late pupal stages.