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|Flybase description||The gene groucho is referred to in FlyBase by the symbol Dmel\gro (CG8384, FBgn0001139).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; transcription corepressor activity.
There is experimental evidence that it is involved in the biological process: lateral inhibition; dendrite morphogenesis; nervous system development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of smoothened signaling pathway; actin filament organization; negative regulation of transcription, DNA-dependent.
118 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system subdivision; adult segment; organ system; adult mesothoracic segment; external compound sense organ; primordium; portion of tissue; sensillum; cell projection; integumentary plate; ventral nerve cord primordium.
It has 8 annotated transcripts and 8 annotated polypeptides.
Protein features are: Groucho/TLE, N-terminal Q-rich domain; Groucho/transducin-like enhancer; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.