Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name gro
Flybase description The gene groucho is referred to in FlyBase by the symbol Dmel\gro (CG8384, FBgn0001139).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.7914 -3.4931 -5.552319 -5.7503 -8.669167 -6.0903 -4.957 -7.50397
    Affimetrix absolute value 5.649 5.814 5.712 5.89 5.653 5.955 6.258 5.374
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; transcription corepressor activity.
There is experimental evidence that it is involved in the biological process: lateral inhibition; dendrite morphogenesis; nervous system development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of smoothened signaling pathway; actin filament organization; negative regulation of transcription, DNA-dependent.
118 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system subdivision; adult segment; organ system; adult mesothoracic segment; external compound sense organ; primordium; portion of tissue; sensillum; cell projection; integumentary plate; ventral nerve cord primordium.
It has 8 annotated transcripts and 8 annotated polypeptides.
Protein features are: Groucho/TLE, N-terminal Q-rich domain; Groucho/transducin-like enhancer; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.