Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name hth
Flybase description The gene homothorax is referred to in FlyBase by the symbol Dmel\hth (CG17117, FBgn0001235).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.806 -21.2624 -40.595232 -25.3188 -26.928789 -48.0741 -46.30673 -28.138612
    Affimetrix absolute value 5.877 3.242 2.884 3.739 4.021 2.982 3.022 3.493
    Affymetric present call in "x" number of chips 3 2 0 2 3 0 1 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific enhancer binding RNA polymerase II transcription factor activity; DNA binding.
There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; compound eye development; specification of segmental identity, antennal segment; specification of segmental identity, head; segmentation; compound eye photoreceptor fate commitment; brain development; imaginal disc-derived wing morphogenesis; haltere morphogenesis; imaginal disc-derived leg morphogenesis.
70 alleles are reported.
The phenotypes of these alleles are annotated with 64 unique terms, many of which group under: organ system subdivision; adult segment; external compound sense organ; abdominal lateral pentascolopidial chordotonal organ lch5; thoracic segment; embryonic segment; antennal segment; appendage segment; cuticle; adult mesothoracic segment.
It has 8 annotated transcripts and 8 annotated polypeptides.
Protein features are: Homeobox; Homeobox KN domain; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages.