Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name kn
Flybase description The gene knot is referred to in FlyBase by the symbol Dmel\kn (CG10197, FBgn0001319).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -62.8588 -32.8148 -41.324546 -62.4641 -67.544169 -70.0257 -68.42058 -46.328126
    Affimetrix absolute value 2.447 2.632 2.848 2.426 2.723 2.438 2.458 2.733
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: innate immune response; response to symbiont; regulation of transcription, DNA-dependent; specification of segmental identity, intercalary segment; head segmentation; dendrite morphogenesis; regulation of lamellocyte differentiation; embryonic development via the syncytial blastoderm; imaginal disc-derived wing vein specification.
25 alleles are reported.
The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: adult segment; hypodermal muscle of larval abdomen; organ system subdivision; organ system; adult mesothoracic segment; A1-7 oblique muscle; cephalopharyngeal skeleton; peripheral nervous system; larval abdominal segment 5; nervous system.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Cell surface receptor IPT/TIG; Helix-loop-helix DNA-binding domain; Immunoglobulin E-set; Immunoglobulin-like fold; Transcription factor COE; Transcription factor COE, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed at stages throughout embryogenesis.