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|Flybase description||The gene knot is referred to in FlyBase by the symbol Dmel\kn (CG10197, FBgn0001319).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: innate immune response; response to symbiont; regulation of transcription, DNA-dependent; specification of segmental identity, intercalary segment; head segmentation; dendrite morphogenesis; regulation of lamellocyte differentiation; embryonic development via the syncytial blastoderm; imaginal disc-derived wing vein specification.
25 alleles are reported.
The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: adult segment; hypodermal muscle of larval abdomen; organ system subdivision; organ system; adult mesothoracic segment; A1-7 oblique muscle; cephalopharyngeal skeleton; peripheral nervous system; larval abdominal segment 5; nervous system.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Cell surface receptor IPT/TIG; Helix-loop-helix DNA-binding domain; Immunoglobulin E-set; Immunoglobulin-like fold; Transcription factor COE; Transcription factor COE, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed at stages throughout embryogenesis.