Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name kni
Flybase description The gene knirps is referred to in FlyBase by the symbol Dmel\kni (CG4717, FBgn0001320).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -0.4202 -1.9286 -19.112833 -28.2122 -41.131619 -19.1945 -7.72379 -8.896021
    Affimetrix absolute value 8.301 6.691 4.007 3.582 3.404 4.313 5.603 5.166
    Affymetric present call in "x" number of chips 3 3 0 0 0 1 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; regulation of mitosis; muscle organ development; epidermis development.
108 alleles are reported.
The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: embryonic abdomen; embryonic segment; multicellular structure; adult segment; organ system; organ system subdivision; abdominal segment 7; thoracic segment; late extended germ band embryo; embryonic abdominal segment 4; dorsal trunk primordium; dorsal branch primordium; embryonic/larval hemocoel.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Nuclear hormone receptor, ligand-binding; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.