Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name knrl
Flybase description The gene knirps-like is referred to in FlyBase by the symbol Dmel\knrl (CG4761, FBgn0001323).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -0.5563 -4.3753 -38.525702 -48.4127 -69.853919 -42.781 -13.62828 -29.890627
    Affimetrix absolute value 8.141 5.506 2.914 2.802 2.638 3.145 4.809 3.361
    Affymetric present call in "x" number of chips 3 3 0 0 0 1 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; ligand-dependent nuclear receptor activity.
There is experimental evidence that it is involved in the biological process: regulation of mitosis.
6 alleles are reported.
The phenotypes of these alleles are annotated with: dorsal closure embryo; metathoracic femur; embryonic dorsal epidermis.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages, during late pupal stages.