Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name kto
Flybase description The gene kohtalo is referred to in FlyBase by the symbol Dmel\kto (CG8491, FBgn0001324).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -8.063 -3.327 -5.509262 -5.8966 -7.706128 -6.1525 -6.58306 -7.352509
    Affimetrix absolute value 5.405 5.888 5.748 5.867 5.838 5.952 5.848 5.539
    Affymetric present call in "x" number of chips 0 2 2 1 1 2 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II transcription cofactor activity.
There is experimental evidence that it is involved in the biological process: bristle development; positive regulation of Wnt receptor signaling pathway; compound eye development; sex comb development; regulation of transcription from RNA polymerase II promoter; leg segmentation.
22 alleles are reported.
The phenotypes of these alleles are annotated with: wing margin; eye disc; trichogen cell; antennal disc; photoreceptor cell; heart primordium; mesothoracic tergum.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Mediator complex, subunit Med12; Mediator complex, subunit Med12, LCEWAV-domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, during early pupal stages.