Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Hlc
Flybase description The gene Helicase is referred to in FlyBase by the symbol Dmel\Hlc (CG1666, FBgn0001565).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 2.0798 1.1558 -1.902695 -0.5857 -2.693133 -1.5608 1.87266 -1.836642
    Affimetrix absolute value 9.464 7.824 7.273 8.085 7.348 7.921 9.418 7.442
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ATP-dependent RNA helicase activity.
There is experimental evidence that it is involved in the biological process: neurogenesis.
21 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; central nervous system; peripheral nervous system; mesothoracic tergum.
It has one annotated transcript and one annotated polypeptide.
Protein features are: DEAD-like helicase; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; RNA helicase, DEAD-box type, Q motif.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression.
Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages.