Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name l(3)mbn
Flybase description The gene lethal (3) malignant blood neoplasm is referred to in FlyBase by the symbol Dmel\l(3)mbn (CG12755, FBgn0002440).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -26.1255 -18.867 -22.696037 -31.5348 -42.689615 -45.5332 -39.10291 -33.269143
    Affimetrix absolute value 3.871 3.384 3.68 3.413 3.364 3.06 3.271 3.207
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: structural constituent of chitin-based cuticle.
There is experimental evidence that it is involved in the biological process: bristle development; wing disc development.
48 alleles are reported.
The phenotypes of these alleles are annotated with: plasmatocyte; embryonic/larval lymph gland; podocyte; melanotic mass; crystal cell.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Insect cuticle protein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression.
Peak expression observed at stages throughout the larval period.