Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name l(3)mbt
Flybase description The gene lethal (3) malignant brain tumor is referred to in FlyBase by the symbol Dmel\l(3)mbt (CG5954, FBgn0002441).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.701 -5.4232 -9.691644 -11.6553 -14.805644 -10.7734 -4.82689 -12.67348
    Affimetrix absolute value 6.195 5.185 4.917 4.871 4.886 5.15 6.33 4.672
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: regulation of preblastoderm mitotic cell cycle; dendrite morphogenesis; negative regulation of gene expression; neuroblast proliferation; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; syncytial nuclear migration.
25 alleles are reported.
The phenotype of these alleles is annotated with: embryonic/larval brain.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Mbt repeat; Sterile alpha motif homology; Sterile alpha motif-type; Sterile alpha motif/pointed.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, in adult female stages.