Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name lea
Flybase description The gene leak is referred to in FlyBase by the symbol Dmel\lea (CG5481, FBgn0002543).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -20.1872 -6.028 -11.798827 -11.5816 -14.301058 -6.5271 -24.85398 -12.999296
    Affimetrix absolute value 4.103 5.044 4.627 4.872 4.971 5.896 3.935 4.607
    Affymetric present call in "x" number of chips 1 3 1 3 3 3 1 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: axon guidance receptor activity; receptor activity.
There is experimental evidence for 12 unique biological process terms, many of which group under: anatomical structure development; organ development; central nervous system development; biological regulation; organ morphogenesis; locomotion; cellular component organization or biogenesis; multicellular organismal process; regulation of biological process; embryonic heart tube development; ventral cord development; localization; regulation of multicellular organismal development.
50 alleles are reported.
The phenotypes of these alleles are annotated with 43 unique terms, many of which group under: organ system subdivision; multi-cell-component structure; nervous system; embryonic/larval neuron; adult segment; hypodermal muscle of larval abdomen; cephalopharyngeal skeleton; commissure; A1-7 transverse muscle; primordium.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Fibronectin type III domain; Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.