Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name l(1)sc
Flybase description The gene lethal of scute is referred to in FlyBase by the symbol Dmel\l(1)sc (CG3839, FBgn0002561).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -46.7293 -24.8615 -41.794442 -39.3872 -61.60107 -44.6711 -50.67266 -39.564299
    Affimetrix absolute value 2.872 3.001 2.842 3.097 2.825 3.092 2.896 2.968
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding; protein heterodimerization activity.
There is experimental evidence that it is involved in the biological process: neurogenesis.
20 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: primordium; sense organ; germ layer; sensillum; portion of tissue; adult segment; organ system subdivision; somatic cell; multicellular structure; adult mesothoracic segment.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Achaete-scute transcription factor-related; Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected.
Peak expression observed within 00-06 hour embryonic stages.