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|Flybase description||The gene E(spl) region transcript m7 is referred to in FlyBase by the symbol Dmel\HLHm7 (CG8361, FBgn0002633).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: startle response; brain morphogenesis; dendrite morphogenesis; neuron development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; locomotion involved in locomotory behavior.
25 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; adult segment; adult mesothoracic segment; sensillum; external compound sense organ; compound cell cluster organ; portion of tissue; integumentary plate; somatic cell; thoracic segment; multi-cell-component structure; organ system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Orange; Orange subgroup.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression.
Peak expression observed within 06-12 hour embryonic stages.