Flygut: an atlas of the Drosophila adult midgut

Mouche Logo lab lemaitre Bbcf logo

Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name mam
Flybase description The gene mastermind is referred to in FlyBase by the symbol Dmel\mam (CG8118, FBgn0002643).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -20.3555 -12.0465 -17.753276 -22.2804 -32.712697 -24.9844 -20.34549 -23.478417
    Affimetrix absolute value 4.084 4.049 4.049 3.929 3.734 3.931 4.214 3.763
    Affymetric present call in "x" number of chips 0 0 0 1 0 1 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: transcription coactivator activity.
There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; heart morphogenesis; apposition of dorsal and ventral imaginal disc-derived wing surfaces; mesodermal cell fate determination; imaginal disc-derived wing margin morphogenesis; somatic stem cell maintenance; bristle morphogenesis; imaginal disc-derived wing morphogenesis; asymmetric cell division.
194 alleles are reported.
The phenotypes of these alleles are annotated with 73 unique terms, many of which group under: organ system subdivision; synaptic neuropil subdomain; antennal segment; adult segment; embryonic/larval neuron; adult mesothoracic segment; presumptive embryonic/larval nervous system; peripheral nervous system; embryonic/larval glial cell; primordium.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Neurogenic mastermind-like, N-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.