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|Flybase description||The gene mastermind is referred to in FlyBase by the symbol Dmel\mam (CG8118, FBgn0002643).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: transcription coactivator activity.
There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; heart morphogenesis; apposition of dorsal and ventral imaginal disc-derived wing surfaces; mesodermal cell fate determination; imaginal disc-derived wing margin morphogenesis; somatic stem cell maintenance; bristle morphogenesis; imaginal disc-derived wing morphogenesis; asymmetric cell division.
194 alleles are reported.
The phenotypes of these alleles are annotated with 73 unique terms, many of which group under: organ system subdivision; synaptic neuropil subdomain; antennal segment; adult segment; embryonic/larval neuron; adult mesothoracic segment; presumptive embryonic/larval nervous system; peripheral nervous system; embryonic/larval glial cell; primordium.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Neurogenic mastermind-like, N-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.