Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name twe
Flybase description The gene twine is referred to in FlyBase by the symbol Dmel\twe (CG4965, FBgn0002673).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -48.6734 -33.5338 -41.581708 -53.8846 -68.776142 -67.7082 -71.23908 -52.575371
    Affimetrix absolute value 2.804 2.57 2.801 2.642 2.664 2.495 2.427 2.545
    Affymetric present call in "x" number of chips 2 2 3 2 2 1 0 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein tyrosine phosphatase activity.
There is experimental evidence that it is involved in the biological process: regulation of meiotic cell cycle; spindle assembly involved in male meiosis; pole cell formation; regulation of syncytial blastoderm mitotic cell cycle; meiotic nuclear envelope disassembly; embryo development; male meiosis; cellularization; spindle assembly involved in female meiosis; spermatogenesis.
17 alleles are reported.
The phenotypes of these alleles are annotated with: yolk; trichogen cell; oocyte; spindle; tormogen cell; spermatocyte; oocyte nucleus.
It has one annotated transcript and one annotated polypeptide.
Protein features are: M-phase inducer phosphatase; Rhodanese-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.