Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name mei-W68
Flybase description The gene meiotic W68 is referred to in FlyBase by the symbol Dmel\mei-W68 (CG7753, FBgn0002716).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -39.7583 -16.2414 -19.402204 -29.5178 -34.836075 -35.6915 -42.75621 -29.743227
    Affimetrix absolute value 3.103 3.607 3.899 3.516 3.639 3.411 3.139 3.375
    Affymetric present call in "x" number of chips 0 2 3 1 3 2 0 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: DNA topoisomerase (ATP-hydrolyzing) activity.
There is experimental evidence that it is involved in the biological process: reciprocal meiotic recombination; oogenesis; early meiotic recombination nodule assembly; late meiotic recombination nodule assembly.
13 alleles are reported.
The phenotypes of these alleles are annotated with: early recombination nodule; late recombination nodule.
It has one annotated transcript and one annotated polypeptide.
Protein features are: DNA topoisomerase VI, subunit A; Spo11/DNA topoisomerase VI, subunit A.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression.
Peak expression observed within 06-12 hour embryonic stages.