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|Flybase description||The gene necrotic is referred to in FlyBase by the symbol Dmel\nec (CG1857, FBgn0002930).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: serine-type endopeptidase inhibitor activity.
There is experimental evidence that it is involved in the biological process: immune response; negative regulation of Toll signaling pathway; antifungal humoral response; regulation of proteolysis.
35 alleles are reported.
The phenotypes of these alleles are annotated with: adult epidermis; adult cuticle; adult integumentary system; adult abdomen; joint.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protease inhibitor I4, serpin; Protease inhibitor I4, serpin, conserved site; Serpin domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression.
Peak expression observed at stages throughout the pupal period, in stages of adults of both sexes.