Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name nkd
Flybase description The gene naked cuticle is referred to in FlyBase by the symbol Dmel\nkd (CG11614, FBgn0002945).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -8.8315 -4.0498 -24.268094 -19.3871 -32.437616 -13.4233 -10.75671 -20.86922
    Affimetrix absolute value 5.272 5.627 3.608 4.148 3.749 4.822 5.159 3.963
    Affymetric present call in "x" number of chips 3 3 1 2 0 3 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; zinc ion binding.
There is experimental evidence that it is involved in the biological process: neuroblast fate specification; segment polarity determination; Wnt receptor signaling pathway, planar cell polarity pathway.
59 alleles are reported.
The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: organ system; abdominal ventral denticle belt; organ system subdivision; adult segment; non-connected developing system; primordium; larval abdominal segment; presumptive embryonic/larval nervous system; spiracle; sensillum.
It has one annotated transcript and one annotated polypeptide.
Protein features are: EF-HAND 2; EF-Hand 1, calcium-binding site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.