Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name numb
Flybase description The gene numb is referred to in FlyBase by the symbol Dmel\numb (CG3779, FBgn0002973).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -10.6145 -3.2718 -5.613797 -5.1167 -9.71354 -8.963 -5.63827 -8.028047
    Affimetrix absolute value 5.01 5.919 5.701 6.085 5.5 5.399 6.076 5.275
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence for 11 unique biological process terms, many of which group under: anatomical structure development; biological regulation; multicellular organismal process; regulation of biological process; localization; cell division; regulation of multicellular organismal development; organ development; cell fate commitment; regulation of developmental process.
84 alleles are reported.
The phenotypes of these alleles are annotated with 210 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; adult abdominal myoblast; larval abdominal segment 5; organ system subdivision; A1-7 oblique muscle; embryonic/larval neuron; abdominal segment 7; nervous system; A1-7 transverse muscle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: NUMB domain; Numb/numb-like; Phosphotyrosine interaction domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages.