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|Flybase description||The gene numb is referred to in FlyBase by the symbol Dmel\numb (CG3779, FBgn0002973).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence for 11 unique biological process terms, many of which group under: anatomical structure development; biological regulation; multicellular organismal process; regulation of biological process; localization; cell division; regulation of multicellular organismal development; organ development; cell fate commitment; regulation of developmental process.
84 alleles are reported.
The phenotypes of these alleles are annotated with 210 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; adult abdominal myoblast; larval abdominal segment 5; organ system subdivision; A1-7 oblique muscle; embryonic/larval neuron; abdominal segment 7; nervous system; A1-7 transverse muscle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: NUMB domain; Numb/numb-like; Phosphotyrosine interaction domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages.