Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name pbl
Flybase description The gene pebble is referred to in FlyBase by the symbol Dmel\pbl (CG8114, FBgn0003041).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.1194 -4.6165 -5.135516 -5.6173 -10.616963 -6.1841 1.60389 -4.81789
    Affimetrix absolute value 6.107 5.443 5.816 5.904 5.37 5.965 9.2 6.0
    Affymetric present call in "x" number of chips 3 3 1 2 1 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: guanyl-nucleotide exchange factor activity.
There is experimental evidence for 14 unique biological process terms, many of which group under: anatomical structure development; cell cycle; cell division; cell cycle process; cellular component organization or biogenesis; biological regulation; localization; regulation of developmental process; embryonic hindgut morphogenesis; mesoderm morphogenesis; cell adhesion; cytokinesis after meiosis; establishment of protein localization; regulation of multicellular organismal development.
43 alleles are reported.
The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system subdivision; primordium; external compound sense organ; germ layer; cytoplasmic part; adult segment; organelle; ventral nerve cord primordium; presumptive embryonic/larval nervous system; adult mesothoracic segment.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: BRCT; Dbl homology (DH) domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.