Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name phl
Flybase description The gene pole hole is referred to in FlyBase by the symbol Dmel\phl (CG2845, FBgn0003079).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.4712 -2.1693 -3.290051 -3.6534 -5.55848 -4.7659 -4.17307 -5.00126
    Affimetrix absolute value 5.967 6.503 6.475 6.542 6.301 6.312 6.512 6.012
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; protein serine/threonine kinase activity.
There is experimental evidence for 19 unique biological process terms, many of which group under: anatomical structure development; biological regulation; regulation of biological process; cellular process involved in reproduction; hemocyte differentiation; multicellular organismal reproductive process; signaling; post-embryonic organ morphogenesis; macromolecule modification; positive regulation of cell proliferation; organ development; anterior/posterior axis specification; instar larval development.
93 alleles are reported.
The phenotypes of these alleles are annotated with 60 unique terms, many of which group under: organ system subdivision; external compound sense organ; adult segment; embryonic abdomen; adult mesothoracic segment; peripheral nervous system; hemocyte; embryonic segment; spermatocyte; primordium.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Raf-like Ras-binding; Serine-threonine/tyrosine-protein kinase; Serine/threonine-protein kinase, active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.