Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Pu
Flybase description The gene Punch is referred to in FlyBase by the symbol Dmel\Pu (CG9441, FBgn0003162).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 3.2176 -0.1445 -50.801655 -60.2853 -81.564707 -54.1491 -15.82897 -9.938833
    Affimetrix absolute value 10.074 7.802 2.516 2.474 2.415 2.813 4.611 5.008
    Affymetric present call in "x" number of chips 3 3 0 0 0 1 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: GTP cyclohydrolase I regulator activity; GTP cyclohydrolase I activity.
There is experimental evidence that it is involved in the biological process: preblastoderm mitotic cell cycle; regulation of GTP cyclohydrolase I activity; cuticle pigmentation; pteridine biosynthetic process; regulation of epithelial cell migration, open tracheal system; embryonic pattern specification; compound eye pigmentation; larval chitin-based cuticle development.
80 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; cuticle; extended germ band embryo; multicellular structure; adult segment; adult mesothoracic segment; integumentary system; blastoderm embryo; acellular anatomical structure; somatic cell; sensillum; cephalopharyngeal skeleton; external compound sense organ.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: GTP cyclohydrolase I; GTP cyclohydrolase I, conserved site; GTP cyclohydrolase I/Nitrile oxidoreductase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression.
Peak expression observed during late larval stages, at stages throughout the pupal period.