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|Flybase description||The gene runt is referred to in FlyBase by the symbol Dmel\run (CG1849, FBgn0003300).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; axon guidance; dendrite morphogenesis; germ-band extension; eye morphogenesis; positive regulation of transcription, DNA-dependent.
100 alleles are reported.
The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system subdivision; organ system; external compound sense organ; nervous system; cuticle; thoracic segment; embryonic segment; abdominal ventral denticle belt; extended germ band embryo; abdominal segment 7; gland; abdominal segment 8; abdominal segment 10; embryonic/larval neuron; cephalopharyngeal skeleton.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Acute myeloid leukemia 1 (AML 1)/Runt; Acute myeloid leukemia 1 protein (AML 1)/Runt; p53-like transcription factor, DNA-binding; p53/RUNT-type transcription factor, DNA-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed within 00-12 hour embryonic stages.