Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name sad
Flybase description The gene shadow is referred to in FlyBase by the symbol Dmel\sad (CG14728, FBgn0003312).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -39.2443 -23.8485 -27.870902 -34.5007 -40.968521 -41.601 -37.79536 -30.65762
    Affimetrix absolute value 3.12 3.15 3.401 3.29 3.409 3.184 3.328 3.368
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: ecdysteroid 2-hydroxylase activity.
There is experimental evidence that it is involved in the biological process: motor axon guidance; central nervous system development; dorsal closure; ecdysone biosynthetic process; head involution; midgut development.
14 alleles are reported.
The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; multicellular structure; organ system subdivision; nervous system; non-connected developing system; presumptive embryonic/larval nervous system; portion of tissue; cuticle; multi-cell-component structure; integumentary system; cephalopharyngeal skeleton; axon; commissure.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.