Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Scr
Flybase description The gene Sex combs reduced is referred to in FlyBase by the symbol Dmel\Scr (CG1030, FBgn0003339).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -60.6157 -32.0963 -52.853057 -55.8582 -65.689604 -73.997 -63.96356 -53.770718
    Affimetrix absolute value 2.498 2.617 2.473 2.585 2.726 2.355 2.557 2.517
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: sex comb development.
99 alleles are reported.
The phenotypes of these alleles are annotated with 45 unique terms, many of which group under: organ system subdivision; adult segment; embryonic segment; primordium; embryonic abdomen; mouthpart; external compound sense organ; antennal segment; larval labial segment; presumptive embryonic/larval nervous system; gland.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Homeobox; Homeobox protein, antennapedia type; Homeobox protein, antennapedia type, conserved site; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 06-24 hour embryonic stages, during late larval stages, during early pupal stages.