Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Sh
Flybase description The gene Shaker is referred to in FlyBase by the symbol Dmel\Sh (CG12348, FBgn0003380).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -37.2373 -21.4891 -27.658804 -38.9967 -46.334792 -38.561 -26.53227 -30.279687
    Affimetrix absolute value 3.195 3.233 3.412 3.108 3.233 3.293 3.838 3.35
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: voltage-gated cation channel activity.
There is experimental evidence that it is involved in the biological process: regulation of action potential; regulation of circadian sleep/wake cycle, sleep; detection of visible light; proboscis extension reflex; flight behavior; sleep; axon extension; larval locomotory behavior; regulation of synaptic activity.
67 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; organ system subdivision; nervous system; somatic cell; adult; synapse; adult segment; peripheral nervous system; multicellular structure; embryonic/larval neuron; non-connected developing system; adult cuticle; external compound sense organ.
It has 11 annotated transcripts and 11 annotated polypeptides.
Protein features are: BTB/POZ fold; BTB/POZ-like; Ion transport; Potassium channel, voltage dependent, Kv; Potassium channel, voltage dependent, Kv, tetramerisation; Potassium channel, voltage dependent, Kv1; Voltage-dependent potassium channel.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected.
Peak expression observed during late pupal stages.