|Home||Overview of gut regions||Anatomy||Histology||Transgene expression mapping||Gene expression|
|Search expression data by gene:|
|Flybase description||The gene Shaker is referred to in FlyBase by the symbol Dmel\Sh (CG12348, FBgn0003380).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: voltage-gated cation channel activity.
There is experimental evidence that it is involved in the biological process: regulation of action potential; regulation of circadian sleep/wake cycle, sleep; detection of visible light; proboscis extension reflex; flight behavior; sleep; axon extension; larval locomotory behavior; regulation of synaptic activity.
67 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; organ system subdivision; nervous system; somatic cell; adult; synapse; adult segment; peripheral nervous system; multicellular structure; embryonic/larval neuron; non-connected developing system; adult cuticle; external compound sense organ.
It has 11 annotated transcripts and 11 annotated polypeptides.
Protein features are: BTB/POZ fold; BTB/POZ-like; Ion transport; Potassium channel, voltage dependent, Kv; Potassium channel, voltage dependent, Kv, tetramerisation; Potassium channel, voltage dependent, Kv1; Voltage-dependent potassium channel.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected.
Peak expression observed during late pupal stages.