Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name sisA
Flybase description The gene sisterless A is referred to in FlyBase by the symbol Dmel\sisA (CG1641, FBgn0003411).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -37.4842 -25.7973 -36.543896 -43.245 -51.920973 -48.0462 -47.52337 -36.766065
    Affimetrix absolute value 3.194 2.957 3.027 2.955 3.071 2.984 2.995 3.109
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding RNA polymerase II transcription factor activity; protein heterodimerization activity.
There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; posterior midgut development; primary sex determination; anterior midgut development; endoderm development; sex determination.
15 alleles are reported.
The phenotypes of these alleles are annotated with: yolk granule; yolk.
It has one annotated transcript and one annotated polypeptide.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected.
Peak expression observed within 00-12 hour embryonic stages.