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|Flybase description||The gene smoothened is referred to in FlyBase by the symbol Dmel\smo (CG11561, FBgn0003444).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: blastoderm segmentation; smoothened signaling pathway; eye-antennal disc morphogenesis; ovarian follicle cell development; somatic stem cell maintenance; regulation of mitotic cell cycle; negative regulation of S phase of mitotic cell cycle; eye morphogenesis; Bolwig's organ morphogenesis.
203 alleles are reported.
The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: adult segment; organ system subdivision; organ system; abdominal ventral denticle belt; adult mesothoracic segment; larval abdominal segment; primordium; nervous system; embryonic/larval tracheal system; multi-cell-component structure.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Frizzled domain; Frizzled protein; Frizzled-related; GPCR, family 2-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.