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|Flybase description||The gene spindle A is referred to in FlyBase by the symbol Dmel\spn-A (CG7948, FBgn0003479).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: recombinase activity.
There is experimental evidence that it is involved in the biological process: germarium-derived oocyte fate determination; female meiosis; double-strand break repair via synthesis-dependent strand annealing; polarity specification of dorsal/ventral axis; intracellular mRNA localization; cell cycle checkpoint; oogenesis; polarity specification of anterior/posterior axis; karyosome formation.
29 alleles are reported.
The phenotypes of these alleles are annotated with: germline cyst; chorion; egg; oocyte; presumptive oocyte; karyosome; egg chamber; dorsal appendage; nurse cell; synaptonemal complex.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: ATPase, AAA+ type, core; DNA recombination and repair protein Rad51, C-terminal; DNA recombination and repair protein, RecA-like; DNA recombination/repair protein Rad51; DNA recombination/repair protein RecA, monomer-monomer interface; DNA recombination/repair protein RecA/RadB, ATP-binding domain; DNA repair Rad51/transcription factor NusA, alpha-helical; Helix-hairpin-helix DNA-binding motif, class 1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.