Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name spz
Flybase description The gene spatzle is referred to in FlyBase by the symbol Dmel\spz (CG6134, FBgn0003495).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.1357 -3.8614 -31.149358 -33.8679 -45.944337 -33.586 -2.68759 -23.447271
    Affimetrix absolute value 7.471 5.69 3.251 3.32 3.254 3.543 7.147 3.836
    Affymetric present call in "x" number of chips 3 3 0 0 0 1 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: growth factor activity; protein homodimerization activity; Toll binding.
There is experimental evidence for 13 unique biological process terms, many of which group under: defense response; biological regulation; immune response; multi-organism process; anatomical structure development; regulation of biological process; response to stress; defense response to fungus; dorsal/ventral axis specification; cellular component organization or biogenesis; cellular process involved in reproduction.
68 alleles are reported.
The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic/larval fat body; embryonic/larval hemocoel; embryonic/larval somatic muscle.
It has 12 annotated transcripts and 12 annotated polypeptides.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages.