Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name sqh
Flybase description The gene spaghetti squash is referred to in FlyBase by the symbol Dmel\sqh (CG3595, FBgn0003514).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 7.0479 11.1343 5.757228 10.0222 4.430186 7.6772 4.56007 5.998617
    Affimetrix absolute value 11.225 11.086 10.695 11.701 10.887 11.485 10.698 10.785
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: myosin heavy chain binding.
There is experimental evidence that it is involved in the biological process: border follicle cell migration; nuclear axial expansion; wound healing; cytokinesis; formation of a compartment boundary; cell elongation involved in imaginal disc-derived wing morphogenesis; regulation of tube length, open tracheal system; imaginal disc-derived wing hair organization; regulation of actin cytoskeleton organization; neurogenesis.
31 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; female germline cyst; portion of tissue; organ system subdivision; egg; adult segment; thoracic segment; imaginal precursor; hub cell; extended germ band embryo; cellular component organization or biogenesis; actomyosin contractile ring; external compound sense organ.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand; EF-hand-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.