Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name tkv
Flybase description The gene thickveins is referred to in FlyBase by the symbol Dmel\tkv (CG14026, FBgn0003716).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.5816 3.0976 1.486251 0.3403 -0.318932 2.2089 0.44946 0.47112
    Affimetrix absolute value 7.065 9.225 8.71 8.397 8.765 9.702 8.693 8.406
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: transforming growth factor beta receptor activity, type I; transforming growth factor beta binding.
There is experimental evidence for 23 unique biological process terms, many of which group under: anatomical structure development; biological regulation; regulation of developmental process; regulation of biological process; regulation of multicellular organismal development; cellular process involved in reproduction; organ development; cellular component organization or biogenesis; localization; multicellular organismal reproductive process; post-embryonic organ morphogenesis.
113 alleles are reported.
The phenotypes of these alleles are annotated with 88 unique terms, many of which group under: organ system subdivision; adult segment; organ system; adult mesothoracic segment; primordium; late extended germ band embryo; embryonic/larval tracheal system; nervous system; non-connected developing system; germarium; egg; synapse; external compound sense organ.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain; TGF beta receptor, GS motif; TGF-beta receptor/activin receptor, type I/II.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.