Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name tld
Flybase description The gene tolloid is referred to in FlyBase by the symbol Dmel\tld (CG6868, FBgn0003719).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -49.7823 -24.1721 -35.924665 -51.3621 -65.519575 -54.3731 -49.12629 -39.436672
    Affimetrix absolute value 2.774 3.028 3.02 2.713 2.742 2.797 2.943 2.953
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity.
There is experimental evidence that it is involved in the biological process: torso signaling pathway; terminal region determination; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; protein maturation by peptide bond cleavage.
94 alleles are reported.
The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; organ system subdivision; adult segment; portion of tissue; extended germ band embryo; adult mesothoracic segment; nervous system; non-connected developing system; organelle; primordium; epithelial furrow; external compound sense organ; late extended germ band embryo.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Bone morphogenetic protein 1/tolloid-like protein; CUB; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like, type 3; Metallopeptidase, catalytic domain; Peptidase M12A, astacin; Peptidase, metallopeptidase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.