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|Flybase description||The gene tolloid is referred to in FlyBase by the symbol Dmel\tld (CG6868, FBgn0003719).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity.
There is experimental evidence that it is involved in the biological process: torso signaling pathway; terminal region determination; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; protein maturation by peptide bond cleavage.
94 alleles are reported.
The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; organ system subdivision; adult segment; portion of tissue; extended germ band embryo; adult mesothoracic segment; nervous system; non-connected developing system; organelle; primordium; epithelial furrow; external compound sense organ; late extended germ band embryo.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Bone morphogenetic protein 1/tolloid-like protein; CUB; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like, type 3; Metallopeptidase, catalytic domain; Peptidase M12A, astacin; Peptidase, metallopeptidase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.