Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Tm1
Flybase description The gene Tropomyosin 1 is referred to in FlyBase by the symbol Dmel\Tm1 (CG4898, FBgn0003721).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.4028 -3.6543 -4.29036 -3.7678 -6.596451 -5.5812 -6.40486 -5.677107
    Affimetrix absolute value 5.756 5.749 6.081 6.476 6.057 6.095 5.879 5.781
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: actin binding.
There is experimental evidence that it is involved in the biological process: regulation of lamellipodium assembly; dendrite morphogenesis; pole plasm oskar mRNA localization.
52 alleles are reported.
The phenotypes of these alleles are annotated with: pole cell; germline cell; mesothoracic tergum.
It has 15 annotated transcripts and 15 annotated polypeptides.
Protein features are: Tropomyosin.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes.