Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name tup
Flybase description The gene tailup is referred to in FlyBase by the symbol Dmel\tup (CG10619, FBgn0003896).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -12.5694 -6.0741 -54.093806 -58.8938 -84.604492 -70.8499 -67.59791 -44.367726
    Affimetrix absolute value 4.759 5.048 2.433 2.518 2.367 2.416 2.506 2.799
    Affymetric present call in "x" number of chips 3 3 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II enhancer sequence-specific DNA binding; sequence-specific enhancer binding RNA polymerase II transcription factor activity; RNA polymerase II activating transcription factor binding.
There is experimental evidence for 15 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular component organization or biogenesis; organ development; embryonic development via the syncytial blastoderm; regulation of cellular macromolecule biosynthetic process; sensory organ development; locomotion; anterior/posterior axis specification; notum cell fate specification; tripartite regional subdivision; lymph gland development; tissue homeostasis.
21 alleles are reported.
The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: organ system subdivision; synaptic neuropil subdomain; adult segment; antennal segment; multi-cell-component structure; cephalopharyngeal skeleton; adult mesothoracic segment; pharyngeal sclerite; appendage segment; extended germ band embryo.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Zinc finger, LIM-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages.