Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name twi
Flybase description The gene twist is referred to in FlyBase by the symbol Dmel\twi (CG2956, FBgn0003900).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -18.0658 -16.4736 -24.757977 -28.1525 -36.079917 -35.0 -11.04731 -26.329336
    Affimetrix absolute value 4.236 3.585 3.548 3.586 3.601 3.443 5.1 3.575
    Affymetric present call in "x" number of chips 0 0 0 1 0 0 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein heterodimerization activity; protein homodimerization activity; DNA binding.
There is experimental evidence that it is involved in the biological process: mesodermal cell fate commitment; muscle fiber development; Malpighian tubule morphogenesis; regulation of striated muscle tissue development; actomyosin structure organization; salivary gland morphogenesis; mesoderm development.
57 alleles are reported.
The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; primordium; adult segment; portion of tissue; late extended germ band embryo; adult mesothoracic segment; non-connected developing system; organ system subdivision; germ layer; adult somatic muscle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Twist.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.